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In such events, the protein degradation capacity of proteasome could be greatly overwhelmed

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Abbreviations Con A: Concanavalin A ROS: reactive oxygen species Gpx1: glutathione peroxidase 1 WT mice: wild-type mice Gpx1 KO mice: glutathione peroxidase 1 knockout mice AST: aspartate transaminase ALT: alanine transaminase MS: mercaptosuccinic acid NAC: N-acetylcystein AIH: autoimmune hepatitis GSH: glutathione GSSG: oxidized glutathione MDA: malondialdehyde References Krawitt EL